The central theme of our lab’s research is to leverage the principles of mechanobiology and nanotechnology to tackle chronic vascular inflammation associated with diabetes and aging, major risk factors for various debilitating and intractable conditions. Of these, our lab specifically focuses on diabetic retinopathy (DR) and age-related macular degeneration (AMD), two inflammatory eye diseases that are the leading cause of vision loss in the global diabetic and aging population, respectively. Although current clinical therapies aim to resolve the advanced stages of DR and AMD, there is growing recognition that more effective management of these conditions can be achieved by tackling the disease at the early stage that is marked by vascular inflammation and atrophy. The aim of our research is to precisely address this unmet need. To achieve this goal, we integrate the multidisciplinary principles and techniques related to vascular biology, inflammation, mechanobiology, bioengineering, and nanomaterials. Since vascular inflammation is strongly implicated in DR and AMD pathogenesis, our efforts to identify new anti-inflammatory targets and develop smarter drug delivery approaches has important clinical implications.
Our research is currently being funded by two R01 grants from the NIH/NEI, an AMD grant from the BrightFocus Foundation, the UC Regents Faculty Development Award, and a Collaborative Seed Grant from the UC Office of Research and Economic Development.
Oct 2018 - Congratulations and best wishes to Andrea Cabrera on joining the University of New Mexico's School of Medicine for postdoctoral training!
Sep 2018 - Prof. Ghosh gives a seminar entitled “Vascular Stiffening as a new Paradigm of Inflammatory Eye Diseases” in the Dept. of Pharmacology at Case Western
July 2018 - Congratulations to Andrea Cabrera for successfully defending her doctoral dissertation!
June 2018 - Prof. Ghosh gives a seminar entitled “Learning the Hard Way: Role of Vascular Stiffening in Inflammatory Eye Diseases” at Stony Brook University