University of California, Riverside

Ghosh Research Group



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Welcome to the home page of Ghosh Research Group!

The central theme of our lab’s research is to leverage the principles of mechanobiology and nanotechnology to tackle chronic vascular inflammation associated with diabetes and aging, major risk factors for various debilitating and intractable conditions. Of these, our lab specifically focuses on diabetic retinopathy (DR) and age-related macular degeneration (AMD), two inflammatory eye diseases that are the leading cause of vision loss in the global diabetic and aging population, respectively. Although current clinical therapies aim to resolve the advanced stages of DR and AMD, there is growing recognition that more effective management of these conditions can be achieved by tackling the disease at the early stage that is marked by vascular inflammation and atrophy. The aim of our research is to precisely address this unmet need. To achieve this goal, we integrate the multidisciplinary principles and techniques related to vascular biology, inflammation, mechanobiology, bioengineering, and nanomaterials. Since vascular inflammation is strongly implicated in DR and AMD pathogenesis, our efforts to identify new anti-inflammatory targets and develop smarter drug delivery approaches has important clinical implications.

Our research is currently being funded by two R01 grants from the NIH/NEI, an AMD grant from the BrightFocus Foundation, the UC Regents Faculty Development Award, and a Collaborative Seed Grant from the UC Office of Research and Economic Development.

Open Positions: Two postdoctoral positions in vascular inflammation are available immediately for NIH- and BrightFocus Foundation-funded research on age-related macular degeneration and diabetic retinopathy.                      

 Recent News

July 2018 - Two postdoc positions in vascular inflammation are available immediately for NIH- and BrightFocus Foundation-funded research on diabetic retinopathy and age-related macular degeneration

June 2018 - Prof. Ghosh gives a seminar entitled Learning the Hard Way: Role of Vascular Stiffening in Inflammatory Eye Diseases” at Stony Brook University

June 2018 - Andrea Cabrera presents a poster entitled Impaired lysosomal exocytosis contributes to complement-mediated vascular injury associated with dry AMD" at the 2018 UC Systemwide Bioengineering Symposium in Riverside

June 2018- Congratulations to Neha Palegar for successfully defending her MS thesis! Her thesis was entitled "Site-targeted biomimetic nanoparticles for local suppression of retinal vascular inflammation in diabetes"

May 2018 - Andrea Cabrera gives a talk entitled Role of endothelial cell stiffening in choriocapillaris atrophy associated with dry AMD" at the 2018 ARVO Annual Meeting in Honolulu, HI

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

College Information

Bourns College of Engineering
446 Winston Chung Hall

Tel: (951) 827-5190
Fax: (951) 827-3188
E-mail: collegeinfo@engr.ucr.edu

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